Section Review Central & Peripheral Nervous Systems: Alzheimer's disease and β-amyloid: patent activity between May 1995 and July 1996

Abstract

The patent literature describing activity relating to β-amyloid (Aβ) and Alzheimer's disease (AD) from May 1995 to July 1996 is reviewed. Inventions are classified into five groups: therapeutics that influence Aβ production, therapeutics based on interfering with Aβ aggregation and deposition, therapeutics based on interfering with Aβ neurotoxicity, diagnostics and animal models. While new chemical entities are described as therapeutic agents, the clinical development of these compounds is hindered by the lack of a widely available animal model which mimics the pathology of AD.