Patent Evaluation Pulmonary-Allergy, Dermatological, Gastrointestinal & Arthritis: Anti-C5 monoclonal antibody: a novel anti-inflammatory agent

Abstract

C5 is a key component of the complement system, responsible for the development of cell lysis and chemotaxis for a variety of cell types. It plays a key role in the initiation and the maintenance of the inflammatory response. A monoclonal antibody to mouse C5 has been shown to reduce polymorphonuclear (PMN) cell infiltrate and preserve joint structure in a mouse model of arthritis, when administered after disease onset.