Patent Analysis Pulmonary-Allergy, Dermatological, Gastrointestinal & Arthritis: Interleukin-1 antagonists: patent analysis 1990–1995

Abstract

Modulation of cytokine activity using drugs that interfere with cytokine processing and their signalling pathways is considered a potential route to the therapy of diseases involving cytokine overproduction. This article concentrates on the development of receptor antagonists for the cytokine, interleukin-1 (IL-1), with possible uses in therapies for diseases such as rheumatoid arthritis, asthma, and general autoimmune diseases. It lists the companies investing the most in IL-1 receptor antagonist research by analysis of their patenting activity in this area and provides a picture of the compounds currently in development.