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Abstract
Anxiety disorders include generalised anxiety disorders, panic disorders and obsessive-compulsive disorders. Patients suffer chronic and persistent apprehension and tension not relating to any real danger and this causes physical symptoms which interfere with everyday activities. Benzodiazepines were widely used but have a serious side-effect profile, so newer anxiolytic drugs are required. This review highlights the patent activity, drugs in development and the leading pharmaceutical companies in this area over the period 1990 through to 1995.