Patent Analysis Central & Peripheral Nervous Systems: NMDA receptor antagonists: Patent analysis 1990–1995

Abstract

The publication twelve years ago of evidence supporting the use of N-methyl-D-aspartate (NMDA) receptor antagonists as neuroprotectives in animal models of head injury has provoked a great deal of interest in the use of NMDA receptor antagonists in humans to prevent the significant secondary insults caused by head trauma (such as cellular hypoxia and brain swelling) which occur in the post-injury period, i.e., to act as neuroprotectives. This article analyses the trends in research, identifying the key compounds in development with a focus on future drugs.