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Abstract
This patent discloses oligonucleotide analogues which are able to inhibit human cytomegalovirus (CMV) replication. These oligonucleotides are directed against the mRNA of several genes required for viral DNA replication (UL36, UL84, UL101X-102, UL112–113). This target has not been previously identified as a requirement for viral DNA replication. Activity has been demonstrated in vitro when the oligonucleotides are administered 16hours before viral infection of the cells.