Phosphono substituted tetrazole derivatives as endothelin-converting enzyme inhibitors

Abstract

This patent, from Ciba-Geigy AG, discloses a series of phosphono substituted tetrazole derivatives as ECE inhibitors and claims them as useful in the treatment of pulmonary hypertension, cerebral ischaemia, subarachnoid haemorrhage, renal failure, atherosclerosis, cerebral vasospasm, arterial hypertrophy, restenosis, arrhythmia and myocardial infarction, endotoxic shock, pre-eclampsia, diabetes (e.g., diabetic nephropathy) and Raynaud's disease