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Abstract
The patent literature pertaining to agents for the treatment of migraine headache and related disorders has been reviewed for the period of July 1, 1995 to December 31, 1996. Included are patents on serotonergic agents, such as 5-hydroxytryptamine 1D (5-HT1D) receptor subtype agonists and 5-HT2 and 5-HT3 antagonists. Also covered are patents describing chemical entities that may be effective in migraine therapy based on their pharmacological actions as adrenergic agents, tachykinin receptor antagonists or inhibitors of nitric oxide synthetase (NOS). Selected references from the recent scientific literature have also been cited.