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Abstract
The application of molecular biological techniques has revealed the existence of gene products encoding several novel putative receptors for the neurotransmitter 5-hydroxytryptamine (5-HT). For most of these novel receptors, no prior pharmacological or functional data existed, and the present challenges to pharmacologists are to identify tools to study these gene products, to determine whether or not they function as endogenous receptors and to determine potential therapeutic uses of ligands for these receptors. Here, we review work detailing the cloning and characterisation of the 5-HT6 receptor, its distribution and evidence for functional responses mediated by naturally-occurring 5-HT6 receptors.