Applications for regulatory region of nitric oxide synthase isoforms

Abstract

This patent application focuses on new regulatory sites found in the flavin mononucleotide (FMN) binding domain of endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS), the two constitutive nitric oxide synthases (cNOS). The new regulatory sites differ on the two enzymes. The inducible nitric oxide synthase (iNOS) lacks this extra polypeptide insert. It is alleged that this insert acts as an autoinhibitory control by limiting calcium-calmodulin (CaM) binding to the enzyme.

• antibodies
• calmodulin
• nitric oxide
• nitric oxide synthase
• nucleic acids
• peptides
• polypeptides