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Expert Opinion on Therapeutic Patents Volume 8, 1998 - Issue 12
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Review

Recent strategies for the treatment of multi-drug resistance in cancer cells

Iwao Ojima Department of Chemistry, State University of New York at Stony Brook, Stony Brook, NY 11794-3400, USA
,
Pierre-Yves Bounaud Department of Chemistry, State University of New York at Stony Brook, Stony Brook, NY 11794-3400, USA
&
Cecilia Fumero Oderda Department of Chemistry, State University of New York at Stony Brook, Stony Brook, NY 11794-3400, USA
Pages 1587-1598 | Published online: 25 Feb 2005
 
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Abstract

The multi-drug resistance (MDR) phenotype is defined as a cross-resistance to a wide range of structurally and mechanistically diverse anticancer agents. The emergence of the MDR phenotype in tumours seriously affects the outcome of cancer chemotherapy, and thus the development of strategies to overcome MDR in cancer cells becomes essential and of current demand. This review focuses on patents published in 1996 - 1997 detailing MDR modulators and alternative approaches to the treatment of MDR tumours.

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