DNA encoding galanin GALR3 receptors and uses thereof

Abstract

This patent describes a novel galanin receptor subtype, GalR3, characterised at the levels of both nucleic acid and protein. It also claims expression of this receptor in both in vitro and in vivo paradigms and techniques for the isolation of agonists and antagonists at this receptor. Because of the wide distribution of galanin receptors in the central and peripheral nervous systems, ligands acting at GalR3 receptors are claimed to have application in a wide variety of disorders, including abnormal eating behaviours, diabetes mellitus, pain syndromes and Alzheimer’s disease.

• Alzheimer’s disease
• diabetes mellitus
• eating disorders
• galanin
• pain
• receptors