Cyclopeptamine lipopeptide antifungal agents

Abstract

A solid phase mediated automated process was developed and used by researchers at Abbott laboratories to synthesise structurally diverse amino-lipopeptides as antifungal compounds. The cyclopeptamine analogues produced by this method possess an amino or substituted amino functionality in the proline ring (A) (Figure 2). These amino-lipopeptides have good in vitro and in vivo antifungal activity against Candida albicans.

• antifungal
• Candida albicans
• glucan synthase
• lipopetides
• solid phase synthesis