Novel hydantoin derivatives useful as LFA-1 antagonists

Abstract

5-Benzyl-5-methyl-3-phenylhydantoin derivatives are claimed as antagonists of the interaction between the lymphocyte function-associated antigen (LFA-1) and the intercellular adhesion molecule-1 (ICAM-1). Such antagonists have a broad therapeutic potential in the treatment of inflammatory diseases such as asthma and as immunosupressants.

• hydantoin
• immunosuppressant
• integrin antagonist
• intercellular adhesion molecule-1
• lymphocyte function-associated antigen-1