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Miscellaneous

Novel hydantoin derivatives useful as LFA-1 antagonists

Pages 97-99 | Published online: 25 Feb 2005
 

Abstract

5-Benzyl-5-methyl-3-phenylhydantoin derivatives are claimed as antagonists of the interaction between the lymphocyte function-associated antigen (LFA-1) and the intercellular adhesion molecule-1 (ICAM-1). Such antagonists have a broad therapeutic potential in the treatment of inflammatory diseases such as asthma and as immunosupressants.

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