Rho family antagonists and their use to block inhibition of neurite growth

Abstract

Rho, a small GTP binding protein with intrinsic GTPase activity, is known to play a role in convergent signalling pathways which affect cell morphology and motility. This patent presents evidence that antagonism of Rho blocks the neurite growth-inhibitory effects of myelin-associated glycoprotein (MAG). These findings may have clinical applications in the stimulation of axonal regeneration following injury within the CNS, and possibly in the treatment of neurodegenerative disorders.

• Alzheimer’s disease
• C3 transferase
• CNS injury
• CNS regeneration
• myelin-associated glycoprotein
• neurite growth-inhibitory factors (NGIFs)
• Rho