Peroxisome proliferator-activated receptor ligands in atherosclerosis

Juan F Viles-Gonzalez Mount Sinai School of Medicine, Cardiovascular Biology Research Laboratory, Zena and Michael A Wiener Cardiovascular Institute, 1 Gustave L Levy Place, Box 1030, New York, NY 10029, USA

Brian G Choi Mount Sinai School of Medicine, Cardiovascular Biology Research Laboratory, Zena and Michael A Wiener Cardiovascular Institute, 1 Gustave L Levy Place, Box 1030, New York, NY 10029, USA

Valentin Fuster Mount Sinai School of Medicine, Cardiovascular Biology Research Laboratory, Zena and Michael A Wiener Cardiovascular Institute, 1 Gustave L Levy Place, Box 1030, New York, NY 10029, USA

Juan J Badimon Mount Sinai School of Medicine, Cardiovascular Biology Research Laboratory, Zena and Michael A Wiener Cardiovascular Institute, 1 Gustave L Levy Place, Box 1030, New York, NY 10029, USA

Abstract

In this review, the effect of peroxisome proliferator-activated receptor (PPAR) ligands on atherosclerosis is examined. The PPAR-γ agonist thiazolidinediones are currently indicated for the management of Type 2 diabetes mellitus, and the PPAR-α agonist fibrates are used in dyslipidaemia. Here their mechanism of action and the pre-clinical and clinical evidence for the use of these medications for the prevention and treatment of atherosclerotic disease is explored. In addition, the role of PPAR-δ and the possibilities for the role of dual-binding agonists are examined.

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Peroxisome proliferator-activated receptor ligands in atherosclerosis

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Peroxisome proliferator-activated receptor ligands in atherosclerosis

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