Infliximab for chronic obstructive pulmonary disease: towards a more specific inflammation targeting?

Abstract

Chronic obstructive pulmonary disease (COPD) is a predominantly smoking-related condition in which chronic progressive airways obstruction results because of inflammation that is triggered and maintained by the causative agent and enhanced during exacerbations. Inflammation is dominated by neutrophils, and macrophages and their mediators. TNF-α is a proinflammatory cytokine involved in COPD pathogenesis. Treatment of the stable disease is mainly inhalatory with anticholinergics, β₂ agonsists and inhaled corticosteroids being involved in various stages of the disease. Novel therapeutic agents are currently under investigation for COPD treatment and some of them target various inflammation mediators. Infliximab is a monoclonal anti-TNF-α antibody with demonstrated efficacy in other autoimmune diseases, such as Crohn’s disease and rheumatoid arthritis. The current study assesses the scientific rationale for the use of infliximab in COPD patients.

Keywords::

• COPD
• eNO
• infliximab
• TNF-α