Plant histaminase as an investigational drug in splanchnic artery occlusion and reperfusion

Abstract

Background: Amine oxidases are ubiquitous enzymes involved in the metabolism of biogenic amines. Copper amine oxidases catalyze the oxidative deamination of primary amine groups of several biogenic amines, such as putrescine, cadaverine and histamine. Objective: In the present review the effects of a plant amine oxidase (histaminase, EC1.4.3.6), purified from pea seedlings, in the prevention of splanchnic postischemic reperfusion damage are reported. Conclusion: Various studies have clearly indicated that the use of histaminase will offer a good perspective for a novel therapeutic approach in the medical treatment of intestinal ischemia.

Keywords::

• amine oxidases
• ischemia
• reperfusion tissue injury

Acknowledgments

This research was supported by a grant from Ente Cassa di Risparmio of Florence (E.M.).

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