Pharmacotherapy for end-stage coronary artery disease

Neel R Sodha Beth Israel Deaconess Medical Center, Harvard Medical School, Department of Surgery, LMOB 9B, 110 Francis Street, Boston, MA 02215, USA

Louis M Chu Beth Israel Deaconess Medical Center, Harvard Medical School, Department of Surgery, LMOB 9B, 110 Francis Street, Boston, MA 02215, USA

Munir Boodhwani Universite Catholique de Louvain, Cliniques St. Luc, Division of Cardiac Surgery, 10 Ave Hippocrate, Brussels, Belgium

Frank W Sellke Brown University, Warren Alpert School of Medicine, Division of Cardiothoracic Surgery, MOC 500, 2 Dudley Street, Providence, RI 02905, USA +1 401 444 2732; +1 401 444 2380; [email protected]

Abstract

Importance of the field: Coronary artery disease remains the leading cause of mortality in the industrialized world. Despite advances in surgical and catheter-based interventions, a select number of patients remain with no options for invasive therapy. The goal of this review is to discuss the current status of pharmacotherapeutic interventions to treat end-stage coronary artery disease.

Areas covered in this review: Literature review on the topic of therapeutic angiogenesis from 1980 to 2009.

What the reader will gain: Insight into current therapeutic strategies employed to manage end-stage coronary artery disease.

Take home message: A promising approach focuses on augmenting the endogenous angiogenic response to chronic myocardial ischemia via the use of growth factors.

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Pharmacotherapy for end-stage coronary artery disease

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Pharmacotherapy for end-stage coronary artery disease

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