Rivaroxaban for the treatment of acute coronary syndromes

Abstract

Introduction: Recurrent ischemic events after an acute coronary syndrome (ACS) are frequent, despite current antiplatelet therapies and revascularization. Warfarin reduces recurrent ischemia but increases bleeding. Warfarin is difficult to administer with the proportion of time achieving therapeutic international normalized ratios varying within and among individuals. The newer oral anticoagulants have predictable dose–effect relationships and no monitoring is required.

Areas covered: The pharmacology of rivaroxaban, evidence for the use of rivaroxaban in ACS, and the management of bleeding complications are covered in this article.

Expert opinion: Arterial thrombosis is traditionally thought to be more platelet mediated than clotting factor mediated. Nonetheless, in the acute therapy for ACS, anticoagulation is a cornerstone treatment and there is persistent thrombin generation. Research has focused on finding a “sweet spot” of anticoagulation with high anti-ischemic and low bleeding effects. It follows that with chronic therapy post-ACS, there could also be a “sweet-spot” of anticoagulation. This may depend on the intrinsic vascular disease burden, the intervention delivered (stenting or bypass surgery), and background antiplatelet therapy. Rivaroxaban, a new oral factor Xa inhibitor, in a low-dose regimen-reduced ischemic events including mortality across a broad ACS population in the ATLAS-ACS trial with increased bleeding but without increasing fatal bleeding. Rivaroxaban is an attractive new treatment option for ACS.

Keywords::

• acute coronary syndrome
• factor Xa inhibition
• rivaroxaban

Acknowledgments

We thank C Nell, Team Support Administrator, Green Lane Cardiovascular Research Unit, for excellent secretarial assistance.

Notes