Current oral treatments for erectile dysfunction

JS Kalsi The Institute of Urology and Nephrology, University College London, UK and the Wolfson Institute of Biomedical Research, University College London, UK

S Cellek The Institute of Urology and Nephrology, University College London, UK and the Wolfson Institute of Biomedical Research, University College London, UK

A Muneer The Institute of Urology and Nephrology, University College London, UK and the Wolfson Institute of Biomedical Research, University College London, UK

PD Kell The Institute of Urology and Nephrology, University College London, UK and the Wolfson Institute of Biomedical Research, University College London, UK

DJ Ralph The Institute of Urology and Nephrology, University College London, UK and the Wolfson Institute of Biomedical Research, University College London, UK

S Minhas The Institute of Urology and Nephrology, University College London, UK and the Wolfson Institute of Biomedical Research, University College London, UK

Abstract

Erectile dysfunction (ED) is defined as the inability to achieve and maintain a penile erection adequate for satisfactory sexual intercourse. It is a significant male health problem of global dimensions affecting ∼ 150 million men worldwide. A broad range of options are currently available for the management of ED. They include oral agents (phosphodiesterase 5 inhibitors, dopamine agonists and αreceptor blocking drugs), intracavernosal injection (papaverine, phentolamine, prostaglandin E₁, vasoactive intestinal peptide), transurethral vasoactive agents (prostaglandin E₁), vacuum erection devices, vascular surgery and penile prostheses. Here we review the physiology of penile erection and the currently available oral preparations. In addition, novel therapeutic strategies to improve erectile function are discussed.

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Current oral treatments for erectile dysfunction

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