Angiogenesis-related microRNAs in colon cancer

Abstract

Introduction: Angiogenesis, for its fundamental role in cancer growth and metastasis, has become an appealing target in cancer therapy. A number of angiogenesis-related microRNAs (miRNAs) are under investigation and they can affect the cancerous phenotype of malignant cells.

Areas covered: The authors review the recent advances in angiogenesis-related miRNAs in human colon cancer. They also envisage future developments toward potential miRNA-based applications to cancer treatment.

Expert opinion: Angiogenesis-related miRNAs may reasonably be considered as a valuable cancer therapeutic tool. More investigations should be performed to promote therapeutic–clinical research of miRNAs in patients with colon cancer.

Keywords::

• angiogenesis
• colon cancer
• microRNA
• miR-107
• miR-145
• miR-194
• miR-27a
• miR-802

Acknowledgment

L Hong, Y Han and Y Zhou contributed equally to this work.

Notes

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