The emerging therapeutic role of antibody mixtures

Abstract

A body of evidence suggests that a mixture of therapeutic monoclonal antibodies (mAbs) may be better than a single antibody. Several strategies have been developed to achieve multiple targeting, including the administration of two or more mAbs to the patient, bispecific antibodies and antibody mixtures. Recently, new antibody technologies based on a diverse array of antibodies binding to several different epitopes on any given antigen or antigens have been developed. One of the most promising is the Sympress™ manufacturing technology, which allows the production of an antibody mixture in just one bioreactor as a single drug substance. Recombinant antibody mixtures may be applicable to therapy of neoplastic, autoimmune and infectious diseases.

Keywords::

• antibody engineering
• antibody manufacturing
• antibody mixture
• bispecific antibodies
• CL184
• combotox
• rozrolimupab
• Sym004
• therapeutic antibodies
• XOMA 3AB