Toll like receptors in liver ischemia reperfusion injury: A novel target for therapeutic modulation?

Athanasios Katsargyris National and Kapodistrian University of Athens, ‘LAIKON’ Hospital, School of Medicine, Vascular Division, 1st Department of Surgery, 75 Mikras Asias street, Goudi, 11527 Athens, Greece; National and Kapodistrian University of Athens, School of Medicine, Department of Forensic Medicine and Toxicology, 75 M. Asias street, Goudi, GR11527, Athens, Greece +30 210 7462413; +30 210 7716098; [email protected]

, MD,

Chris Klonaris National and Kapodistrian University of Athens, ‘LAIKON’ Hospital, School of Medicine, Vascular Division, 1st Department of Surgery, 75 Mikras Asias street, Goudi, 11527 Athens, Greece

, MD,

Andreas Alexandrou National and Kapodistrian University of Athens, ‘LAIKON’ Hospital, School of Medicine, Vascular Division, 1st Department of Surgery, 75 Mikras Asias street, Goudi, 11527 Athens, Greece

, MD,

Alexander E Giakoustidis University Thessaloniki, Medical School Aristotle, Division of Transplantation, Department of Surgery, Greece

, MD,

Ioanna Vasileiou National and Kapodistrian University of Athens, ‘LAIKON’ Hospital, School of Medicine, Vascular Division, 1st Department of Surgery, 75 Mikras Asias street, Goudi, 11527 Athens, Greece; National and Kapodistrian University of Athens, School of Medicine, Department of Forensic Medicine and Toxicology, 75 M. Asias street, Goudi, GR11527, Athens, Greece +30 210 7462413; +30 210 7716098; [email protected]

, MD &

Stamatios Theocharis National and Kapodistrian University of Athens, School of Medicine, Department of Forensic Medicine and Toxicology, 75 M. Asias street, Goudi, GR11527, Athens, Greece +30 210 7462413; +30 210 7716098; [email protected]

, MD PhD

Abstract

Background: There is increasing evidence that Toll-like receptors (TLRs) sense host tissue damage by engaging with endogenous ligands. TLRs are considered to be involved in many primarily non-immune-related diseases. Hepatic ischemia reperfusion injury (IRI) represents one of these disorders. Objective: To present the latest findings supporting the involvement of TLRs in liver IRI and to explore their role as potential targets for therapeutic intervention. Methods: A review of the literature summarizing the latest advances in TLR signaling, the role of TLRs in each hepatic cell population and the involvement of TLRs in the pathophysiology of hepatic IRI. The potential role of TLR-targeting treatment strategies in liver IRI is discussed. Conclusions: Recent experimental evidence suggests that TLR activation on Kupffer cells provides the triggering signal for pro-inflammatory responses that lead to liver IRI. Modulating TLR signaling could have a beneficial effect in patients with liver IRI.

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Toll like receptors in liver ischemia reperfusion injury: A novel target for therapeutic modulation?

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Toll like receptors in liver ischemia reperfusion injury: A novel target for therapeutic modulation?

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