Should expectant mothers be vaccinated against flu? A safety review

Paul LoubetInserm, CIC Cochin Pasteur, Paris, France;Descartes University, Cochin-hospital, Paris Assistance Publique-Hôpitaux de Paris (AP-HP), Department of Internal Medicine, Infectious disease ward, Paris, France

Solen KerneisInserm, CIC Cochin Pasteur, Paris, France;Descartes University, Cochin-hospital, Paris Assistance Publique-Hôpitaux de Paris (AP-HP), Department of Internal Medicine, Infectious disease ward, Paris, France;Paris Descartes, Sorbonne Paris Cité University, Paris, France

Olivia AnselemAssistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier Cochin-Broca Hôtel-Dieu, Maternité Port-Royal, Paris, France;Descartes University, Cochin-Broca-Hôtel-Dieu hospital, Paris Assistance Publique-Hôpitaux de Paris (AP-HP), Department of Obstetrics and Gynecology, Paris, France;PremUp Foundation for Scientific Cooperation in Connection with Pregnancy and Prematurity, Paris, France;DHU Risk in Pregnancy, Paris, France

Vassilis TsatsarisParis Descartes, Sorbonne Paris Cité University, Paris, France;Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier Cochin-Broca Hôtel-Dieu, Maternité Port-Royal, Paris, France;Descartes University, Cochin-Broca-Hôtel-Dieu hospital, Paris Assistance Publique-Hôpitaux de Paris (AP-HP), Department of Obstetrics and Gynecology, Paris, France;PremUp Foundation for Scientific Cooperation in Connection with Pregnancy and Prematurity, Paris, France;DHU Risk in Pregnancy, Paris, France

Francois GoffinetParis Descartes, Sorbonne Paris Cité University, Paris, France;Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier Cochin-Broca Hôtel-Dieu, Maternité Port-Royal, Paris, France;Descartes University, Cochin-Broca-Hôtel-Dieu hospital, Paris Assistance Publique-Hôpitaux de Paris (AP-HP), Department of Obstetrics and Gynecology, Paris, France;PremUp Foundation for Scientific Cooperation in Connection with Pregnancy and Prematurity, Paris, France;DHU Risk in Pregnancy, Paris, France;Inserm U953, Epidemiological Research Unit on Perinatal Health and Women’s and Children Health, Paris, France

Odile LaunayInserm, CIC Cochin Pasteur, Paris, France;Descartes University, Cochin-hospital, Paris Assistance Publique-Hôpitaux de Paris (AP-HP), Department of Internal Medicine, Infectious disease ward, Paris, France;Paris Descartes, Sorbonne Paris Cité University, Paris, France;Fédération d’infectiologie, Groupe Hospitalier Cochin - Saint Vincent de Paul, 27 rue du Faubourg St Jacques, 75679 Paris Cedex 14, France+33 1 58 41 28 58; +33 1 58 41 29 10; [email protected]

Abstract

Introduction: Pregnant women have a higher risk of serious complications from influenza than non-pregnant women of reproductive age. This increased risk has been noted both during pandemic and inter-pandemic influenza seasons. However, although vaccination against flu is recommended at any trimesters by international and national policies, vaccine coverage remains low in pregnant women, possibly due to patient and healthcare providers’ concern about the safety of the vaccine.

Areas covered: This review addresses the effectiveness and safety of seasonal and adjuvanted and non-adjuvanted pandemic 2009 A/H1N1 influenza vaccine.

Expert opinion: Available data suggest no evidence of an increased risk for any adverse event for both mothers and fetuses after vaccination against flu during pregnancy. These results are important when considering the potential of maternal immunization against flu as a public health intervention to protect both the mother and her infant against serious infectious disease.

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Should expectant mothers be vaccinated against flu? A safety review

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