Degradable polyethylenimines as DNA and small interfering RNA carriers

D Jere Seoul National University, Department of Agricultural Biotechnology, Korea

HL Jiang Seoul National University, Research Institute for Agriculture and Life Sciences, Seoul 151-921, Korea +82 2 880 4636; +82 2 875 2494; [email protected]; Seoul National University, College of Veterinary Medicine, Seoul, Korea

R Arote Seoul National University, Department of Agricultural Biotechnology, Korea; Seoul National University, Research Institute for Agriculture and Life Sciences, Seoul 151-921, Korea +82 2 880 4636; +82 2 875 2494; [email protected]

YK Kim Seoul National University, Department of Agricultural Biotechnology, Korea

YJ Choi Seoul National University, Department of Agricultural Biotechnology, Korea; Seoul National University, Research Institute for Agriculture and Life Sciences, Seoul 151-921, Korea +82 2 880 4636; +82 2 875 2494; [email protected]

MH Cho Seoul National University, College of Veterinary Medicine, Seoul, Korea

T Akaike Tokyo Institute of Technology, Department of Biomedical Engineering, Yokohama, Japan

CS Cho Seoul National University, Department of Agricultural Biotechnology, Korea; Seoul National University, Research Institute for Agriculture and Life Sciences, Seoul 151-921, Korea +82 2 880 4636; +82 2 875 2494; [email protected]

show all

Abstract

Gene therapy is a powerful approach in the treatment of a wide range of both inherited and acquired diseases. Nonviral delivery systems have been proposed as safer alternatives to viral vectors because they avoid the inherent immunogenicity and production problems that are seen when viral systems are used. Many cationic polymers, including high-molecular-weight polyethylenimine (PEI) have been widely studied as gene-delivery carriers, both, in vitro and in vivo. However, interest has recently developed in degradable polymeric systems. The advantage of degradable polymer is its low in-vivo cytotoxicity, which is a result of its easy elimination from the cells and body. Degradable polymer also enhances transfection of DNA or small interfering RNA (siRNA) for efficient gene expression or silencing, respectively. This review paper summarizes and discusses the recent advances with degradable PEIs, such as cross-linked and grafted PEIs for DNA and siRNA delivery.

Keywords::

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Degradable polyethylenimines as DNA and small interfering RNA carriers

Information for

Open access

Opportunities

Help and information

Degradable polyethylenimines as DNA and small interfering RNA carriers

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature