Ceramic nanocarriers: versatile nanosystem for protein and peptide delivery

Abstract

Introduction: Proteins and peptides have been established to be the potential drug candidate for various human diseases. But, delivery of these therapeutic protein and peptides is still a challenge due to their several unfavorable properties. Nanotechnology is expanding as a promising tool for the efficient delivery of proteins and peptides. Among numerous nano-based carriers, ceramic nanoparticles have proven themselves as a unique carrier for protein and peptide delivery as they provide a more stable, bioavailable, readily manufacturable, and acceptable proteins and polypeptide formulation.

Areas covered: This article provides an overview of the various aspects of ceramic nanoparticles including their classification, methods of preparation, latest advances, and applications as protein and peptide delivery carriers.

Expert opinion: Ceramic nanocarriers seem to have potential for preserving structural integrity of proteins and peptides, thereby promoting a better therapeutic effect. This approach thus provides pharmaceutical scientists with a new hope for the delivery of proteins and peptides. Still, considerable study on ceramic nanocarrier is necessary with respect to pharmacokinetics, toxicology, and animal studies to confirm their efficiency as well as safety and to establish their clinical usefulness and scale-up to industrial level.

Keywords::

• ceramic systems
• drug loading
• nanocarriers
• nanoparticles
• preparation methods
• protein delivery
• proteins

Declaration of interest

The authors are thankful to Director, University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.) India for this study and Department of science and technology (DST-FIST) and Chhattisgarh Council of Science and technology (CGCOST/MRP/650), UGC-MRP (UGC/MRP/39-169) for financial assistance relating to this work. The authors report no conficts of interest. The authors alone are responsible for the content and writing of the article.

Notes

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