Design of nanoparticle-based dry powder pulmonary vaccines

Abstract

The development of needle-less vaccination for pulmonary delivery may require dry forms of vaccines whose powder properties allow for a low cost, heat and freeze tolerance, efficient aerosolization, and the ability to target cells of the immune system. For each of these reasons, nanoparticles can play a critical role in the formulation, development and delivery of needle-less vaccination. This review aims to communicate present biomaterial design issues surrounding the incorporation of nanoparticles into pulmonary vaccines.

Keywords::

• adjuvants
• aerosols
• biocompatible polymers
• microparticles
• nanoparticles
• poly(lactic-co-glycolic acid)
• pulmonary delivery
• vaccines

Notes