156
Views
13
CrossRef citations to date
0
Altmetric
Reviews

Design and development of antisense drugs

&
Pages 1189-1207 | Published online: 28 Sep 2008
 

Abstract

Background: With the advent of nucleic acids as therapeutic molecules, the traditional drug discovery and development process has undergone a radical change. Because nucleic acids target complementary sequences and the recognition is on the basis of Watson–Crick base pair formation, the specificity of the whole process is high. The unwanted side reactions, which are a common phenomenon observed with small molecules, are thus cut down. Objectives: The objective of this review is to look at the concept of antisense oligonucleotides as nucleic acid medicines and trace the history of drug molecules based on this concept that are at various stages of advancement. The problems encountered in the development process and the possible delivery routes are critically analyzed. Conclusion: Although specificity and selectivity are the key features of antisense oligonucleotides, the need to target the right tissues and reach the nucleus remains a challenge to overcome.

Notes

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.