5-Hydroxymethyl-oxazolidin-2-one antibacterials

Abstract

The application, WO2008062379, claims chimeric compounds comprising chemically linked 5-hydroxymethyl-oxazolidinone and tetracyclic-quinolone moieties. The claimed compounds are potent expanded-range antibacterial agents against selected Gram-positive and Gram-negative bacteria, which may exhibit dual mode of action as inhibitors of topoisomarases IV and protein synthesis. The structures of the compounds suggest that the linkers are chemically and biochemically stable. This application represents part of recently initiated research efforts at Actelion.

Keywords::

• chimeric molecule
• dual-action antibacterial agents
• fluoroquinolone
• hybrids
• oxazolidinone

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Erratum

Acknowledgement

The authors would like to thank the Faculty of Pharmacy, Kuwait University for providing the facilities during the preparation of this manuscript.