Malignant gliomas: strategies to increase the effectiveness of targeted molecular treatment

Patrick Y Wen Associate Professor of Neurology, Harvard Medical School, Dana-Farber/Brigham and Women’s Cancer Center, SW430D, 44 Binney St, and Division of Neuro-oncology, Department of Neurology, Brigham and Women’ Cancer Hospital, Boston, MA 02115, USA [email protected]

Santosh Kesari Instructor in Neurology, Harvard Medical School, Dana-Farber/Brigham and Women’s Cancer Center, SW430D, 44 Binney St, and Division of Neuro-oncology, Department of Neurology, Brigham and Women’ Cancer Hospital, Boston, MA 02115, USA [email protected]

Jan Drappatz Instructor in Neurology, Harvard Medical School, Dana-Farber/Brigham and Women’s Cancer Center, SW430D, 44 Binney St, and Division of Neuro-oncology, Department of Neurology, Brigham and Women’ Cancer Hospital, Boston, MA 02115, USA [email protected]

Abstract

Recently, there has been increasing interest in the use of targeted molecular agents for the treatment of malignant gliomas. These agents are generally well tolerated but have demonstrated only modest activity. In this article, the current status of targeted molecular agents for malignant gliomas will be reviewed and strategies to improve their effectiveness will be discussed.

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Malignant gliomas: strategies to increase the effectiveness of targeted molecular treatment

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Malignant gliomas: strategies to increase the effectiveness of targeted molecular treatment

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