Use of gene expression microarrays for the study of acute leukemia

Abstract

Genetic lesions found in acute leukemia drive the pathology of the disease in addition to forming reliable classifications of prognosis. However, there is still a reasonable heterogeneity of response among cases with the same genetic lesion. Moreover, many leukemia cases have no detectable genetic marker and these cases have marked heterogeneity of response. How can we learn more about the genes and pathways involved with leukemogenesis and response in the midst of such complexity? Gene expression microarrays are experimental platforms that allow for the simultaneous evaluation of the thousands of mRNA transcripts (the ‘transcriptome’). This technology has revolutionized the study of leukemia, giving insight into genes and pathways involved in disease response and the biology involved in specific translocations.

Keywords::

• gene expression
• leukemia
• microarrays

Acknowledgement

Supported in part by the National Institute of Health grants CA-18029, CA-85053, CA-92405, IARC R.3045 and a Fulbright fellowship grant.