Impact of dose frequency on compliance and health outcomes: a literature review (1966–2006)

Abstract

In order for treatments to be effective, patients must be compliant with their medication regimens. Currently, patient compliance is seen as one of the most challenging issues in treating patients with chronic diseases. Studies in which dose frequency has been changed have been reviewed across several different diseases to examine the impact of a change in dose frequency on compliance and health outcomes, as well as efficacy and tolerability. In general, reducing dose frequency may improve medication compliance and effectiveness, and reduce adverse events, while possibly reducing healthcare costs. Suggestions for future research have been presented, including a need to measure compliance with injectable formulations and a standardized definition of compliance.

Keywords::

• adherence
• clinical effectiveness
• compliance
• delayed-action preparations
• dose-administration schedule
• dose frequency
• dosing
• efficacy
• persistence
• safety

Acknowledgements

This literature review was funded by Eli Lilly and Company. All authors have incorporated some comments from three anonymous reviewers into the paper.