Botulinum toxin type B (Myobloc™, NeuroBloc™): a new choice in cervical dystonia

Abstract

Botulinum toxin has dramatically improved the treatment of cervical dystonia. Prior to the use of botulinum toxin for many neurologic disorders, patients had few effective therapeutic options. Botulinum toxin type B (Myobloc™, NeuroBloc™) is a new antigenically distinct botulinum toxin with a unique structure and mechanism of action. Preclinical studies have demonstrated that im. injections of botulinum toxin type B effectively induce a dose-dependent paralysis. Controlled clinical trials have shown that it is safe and effective in alleviating symptoms associated with cervical dystonia. Given its efficacy and safety profile, the clinical use of type B toxin is anticipated to expand into other therapeutic areas.

• acetylcholine blockade
• botulinum toxin type B
• cervical dystonia
• chemical denervation
• Myobloc
• NeuroBloc
• neuromuscular blocking agent
• neuromuscular disorder
• neurotoxin
• spasmodic torticollis