Acknowledgments
The author would like to thank Prof. David Henshall for critical reading of the manuscript and apologize to those authors whose relevant work could not be cited here due to the strict restrictions on numbers of citations.
Declaration of interest
This work was supported by funding from Science Foundation Ireland and the Health Research Board to T Engel ((13/SIRG/2098 and HRA-POR-2015-1243) and RCSI StAR. The author has no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.