Neuroprotective treatment for Parkinson’s disease

Abstract

Parkinson’s disease is a progressive disorder that may ultimately lead to severe disability. Its course may be slowed or arrested by neuroprotective interventions that influence the basic mechanisms involved in neuronal death. In the last 2 years, claims have been made for several possible neuroprotective treatments, and patients and physicians are increasingly enquiring about such a therapy. The present report summarizes the basis of various potential neuroprotective strategies and the progress that has been made in establishing their validity and clinical utility.

• coenzyme Q10
• creatine
• glial-derived neurotrophic factor
• glutamate toxicity
• minocycline
• monoamine oxidase inhibitors
• neuroprotection
• Parkinson’s disease
• rasagiline
• selegiline
• trial design