Women and epilepsy: review and practical recommendations

Abstract

Individuals with epilepsy experience a number of sex-specific problems. In women, pregnancy and delivery are obvious issues, fertility problems are more often encountered and they also seem to have a higher frequency of sexual problems. A large number of women with epilepsy experience seizure exacerbation in relation to the menstrual cycle and have higher frequencies of menstrual disturbances and polycystic ovaries. Cosmetic problems affecting skin, hair or weight may also be drug induced. The use of antiepileptic drugs may influence the effect of contraceptives leading to unplanned pregnancies and contraceptives may affect the serum levels of antiepileptic drugs. The care of pregnant women with epilepsy requires attention to a number of guidelines and close cooperation between neurologist and gynecologist is recommended. Although the majority of the women with epilepsy experience normal pregnancies and deliveries, their children have a higher risk of birth defects. At menopause, their seizure pattern may change and some antiepileptic drugs may increase the risk of osteoporosis. The optimal treatment of women with epilepsy should take into account these gender-specific issues in the different stages of life.

Keywords::

• antiepileptic drug
• carbamazepine
• catamenial epilepsy
• contraception
• epilepsy
• lamotrigine
• osteoporosis
• pregnancy
• puberty
• valproate

Notes

FSH: Follicle-stimulating hormone; LH: Luteinizing hormone; SHBG: Sex-hormone binding globulin.

FSH: Follicle-stimulating hormone; GnHR: Gonadotropin-releasing hormone; LH: Luteinizing hormone; PCO: Polycystic ovaries; PCOS: PCO syndrome.

AED: Antiepileptic drug; CBZ: Carbamazepine; PB: Phenobarbital; PHT: Phenytoin; VPA: Valproate.

AED: Antiepileptic drug; DXA: Dual energy x-ray absorptiometry.