Acknowledgement
The authors thank Eric Smith for valuable discussion and preparation of the figures.
Financial & competing interests disclosure
This work was supported by the Dana-Farber Cancer Institute and the National Human Genome Research Institute (P50HG004233). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.