Strategies to treat autoimmune diabetes

Abstract

Type 1 diabetes results from autoimmune destruction of insulin-producing β cells in the pancreatic islets, leading to deficiency in glucose uptake by the cells of the body. The resulting complications and mortality call into attention the need for therapeutic strategies to treat this disease. While general immunosuppressive treatment and antigen-based therapy have both proven effective in aborting the autoimmune attack on β cells, cellular therapy and synergistic combination of agents probably represent the most promising approaches for efficient targeting of autoreactive cells. The underlying challenge is fine tuning of immune therapy to avoid harmful side effects on the immune system or other host-defense functions. This should be rendered possible by identifying the optimal regimen and underlying mechanisms of action.

Keywords::

• anti-CD3
• antigen-specific treatment
• autoimmune diabetes
• cellular therapy
• combination therapy
• immune intervention
• regulatory T cell
• systemic immune modulation
• Type 1 diabetes mellitus