Noncoding miRNAs as key controllers of pancreatic β-cell functions

Abstract

miRNAs, a recently discovered family of small noncoding RNAs, are emerging as major controllers of gene expression and key determinants of pancreatic β-cell function. These 19–22-nucleotide molecules govern gene expression by partially pairing to 3´-untranslated regions of target mRNAs and by inhibiting their translation. The elucidation of the role of miRNAs promises to unravel new aspects of β-cell biology and to clarify the mechanisms leading to defective insulin secretion in diabetes mellitus. This information is expected to favor the design of new approaches for preserving functional β-cells in prediabetic stages and the development of strategies for engineering insulin-secreting cells capable of replacing endogenous β-cells in diabetic patients.

Keywords::

• diabetes
• insulin
• P-body
• secretion
• transcription factor