Advanced search
Publication Cover
Expert Review of Endocrinology & Metabolism Volume 8, 2013 - Issue 4
Submit an article Journal homepage
183
Views
37
CrossRef citations to date
0
Altmetric
Review

The FGF/FGF receptor axis as a therapeutic target in breast cancer

Nicholas J Brady Microbiology, Immunology and Cancer Biology Graduate Program, University of Minnesota, 420 Delaware St. SE, MMC 609, Minneapolis, MN 55455, USA; Microbiology, Immunology and Cancer Biology Graduate Program, University of Minnesota, 420 Delaware St. SE, MMC 609, Minneapolis, MN 55455, USA
,
Pavlina Chuntova Microbiology, Immunology and Cancer Biology Graduate Program, University of Minnesota, 420 Delaware St. SE, MMC 609, Minneapolis, MN 55455, USA; Microbiology, Immunology and Cancer Biology Graduate Program, University of Minnesota, 420 Delaware St. SE, MMC 609, Minneapolis, MN 55455, USA
,
Lindsey K Bade Molecular, Cellular, Developmental Biology and Genetics Graduate Program, University of Minnesota, 420 Delaware St. SE, MMC 609, Minneapolis, MN 55455, USA; Molecular, Cellular, Developmental Biology and Genetics Graduate Program, University of Minnesota, 420 Delaware St. SE, MMC 609, Minneapolis, MN 55455, USA
&
Kathryn L Schwertfeger Department of Laboratory Medicine and Pathology, University of Minnesota, 420 Delaware St. SE, MMC 609, Minneapolis, MN 55455, USA. [email protected]; Masonic Cancer Center, University of Minnesota, 420 Delaware St. SE, MMC 609, Minneapolis, MN 55455, USA; Department of Laboratory Medicine and Pathology, University of Minnesota, 420 Delaware St. SE, MMC 609, Minneapolis, MN 55455, USA. [email protected]; Masonic Cancer Center, University of Minnesota, 420 Delaware St. SE, MMC 609, Minneapolis, MN 55455, USA
Pages 391-402 | Published online: 10 Jan 2014
 
Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days

Abstract

FGF receptor (FGFR) signaling is a vital component of both embryonic and postnatal mammary gland development, which has prompted researchers to investigate both its relevance to breast cancer and its potential as a therapeutic target. Deregulated FGFR signaling during breast cancer occurs through various mechanisms, including amplification of the receptor genes, aberrant ligand expression, receptor mutations and translocations. Recent experimental outcomes involving both animal models and human breast cancer cell lines have led to the initiation of multiple early clinical trials investigating the safety and efficacy of small-molecule FGFR inhibitors. In this article, the authors review both the most recent discoveries and the need for further investigation of the mechanisms through which FGF/FGFR signaling has emerged as an oncogenic driver.

Financial & competing interests disclosure

The author has no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related Research Data

A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer
Source: Springer Science and Business Media LLC
Fibroblast growth factors in development and cancer: insights from the mammary and prostate glands.
Source: Bentham Science Publishers Ltd.
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer
Source: Springer Science and Business Media LLC
Fibroblast growth factor signalling: from development to cancer
Source: Springer Science and Business Media LLC
Selective recognition of fibroblast growth factor-2 by the long pentraxin PTX3 inhibits angiogenesis.
Source: American Society of Hematology
Repeated observation of breast tumor subtypes in independent gene expression data sets
Source: The University of North Carolina at Chapel Hill University Libraries
Inducible dimerization of FGFR1: development of a mouse model to analyze progressive transformation of the mammary gland.
Source: Rockefeller University Press
Monocyte/macrophage infiltration in tumors : modulators of angiogenesis
Source: Wiley
Identification of fibroblast growth factor-8b target genes associated with early and late cell cycle events in breast cancer cells.
Source: Elsevier BV
Conditional activation of FGFR1 in the prostate epithelium induces angiogenesis with concomitant differential regulation of Ang-1 and Ang-2.
Source: Springer Science and Business Media LLC
A Critical Role for the Inflammatory Response in a Mouse Model of Preneoplastic Progression
Source: American Association for Cancer Research (AACR)
Roles of Fibroblast Growth Factor Receptors in Carcinogenesis
Source: American Association for Cancer Research (AACR)
Identical mutations in the FGFR2 gene cause both Pfeiffer and Crouzon syndrome phenotypes.
Source: Springer Science and Business Media LLC
Macrophages Promote Fibroblast Growth Factor Receptor-Driven Tumor Cell Migration and Invasion in a Cxcr2-Dependent Manner
Source: American Association for Cancer Research (AACR)
A 1 Mb minimal amplicon at 8p11-12 in breast cancer identifies new candidate oncogenes.
Source: Springer Science and Business Media LLC
AZD4547: An Orally Bioavailable, Potent, and Selective Inhibitor of the Fibroblast Growth Factor Receptor Tyrosine Kinase Family
Source: American Association for Cancer Research (AACR)
8p11 myeloproliferative syndrome: a review.
Source: Elsevier BV
Characterization of fibroblast growth factor receptor 2 overexpression in the human breast cancer cell line SUM-52PE
Source: Springer Nature
Comprehensive genomic profiling of inflammatory breast cancer cases reveals a high frequency of clinically relevant genomic alterations.
Source: Springer Science and Business Media LLC
FGFs/FGFRs-dependent signalling in regulation of steroid hormone receptors – implications for therapy of luminal breast cancer
Source: BMC
Long Pentraxin-3 Inhibits FGF8b-Dependent Angiogenesis and Growth of Steroid Hormone–Regulated Tumors
Source: American Association for Cancer Research (AACR)
ROR1 Potentiates FGFR Signaling in Basal-Like Breast Cancer.
Source: MDPI AG
ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium
Source: Apollo - University of Cambridge Repository
Identification of Targetable FGFR Gene Fusions in Diverse Cancers
Source: American Association for Cancer Research (AACR)
Fibroblast growth factor receptor signaling dramatically accelerates tumorigenesis and enhances oncoprotein translation in the mouse mammary tumor virus-Wnt-1 mouse model of breast cancer
Source: The University of North Carolina at Chapel Hill University Libraries
Endocrine Resistance in Hormone Receptor Positive Breast Cancer-From Mechanism to Therapy.
Source: Frontiers Media SA
Fibroblast Growth Factor Receptor 1 Activation in Mammary Tumor Cells Promotes Macrophage Recruitment in a CX3CL1-Dependent Manner
Source: Public Library of Science (PLoS)
Dietary Fructose Consumption and Triple-Negative Breast Cancer Incidence.
Source: Frontiers Media S.A.
Mutational Analysis of EGFR and Related Signaling Pathway Genes in Lung Adenocarcinomas Identifies a Novel Somatic Kinase Domain Mutation in FGFR4
Source: Public Library of Science (PLoS)
The 11q13-q14 amplicon: clinicopathological correlations and potential drivers.
Source: Wiley
Fibroblast growth factors
Source: Springer Science and Business Media LLC
FGFR2 Abnormalities Underlie a Spectrum of Bone, Skin, and Cancer Pathologies
Source: The Society for Investigative Dermatology, Inc.
Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor Tyrosine Kinase
Source: American Chemical Society (ACS)
microRNA-99b acts as a tumor suppressor in non-small cell lung cancer by directly targeting fibroblast growth factor receptor 3.
Source: Spandidos Publications
Monoclonal antibody antagonists of hypothalamic FGFR1 cause potent but reversible hypophagia and weight loss in rodents and monkeys.
Source: American Physiological Society
Potential for targeting the fibroblast growth factor receptors in breast cancer.
Source: American Association for Cancer Research (AACR)
FGFR1 Amplification Drives Endocrine Therapy Resistance and Is a Therapeutic Target in Breast Cancer
Source: American Association for Cancer Research (AACR)
Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling
Source: National Academy of Sciences (U.S.)
Ponatinib (AP24534), a Multitargeted Pan-FGFR Inhibitor with Activity in Multiple FGFR-Amplified or Mutated Cancer Models
Source: American Association for Cancer Research (AACR)
Regulation of vascular development by fibroblast growth factors.
Source: Springer Science and Business Media LLC

Linking provided by 

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.