Acknowledgements
There is a vast volume of literature of outstanding original articles that, regrettably, could not be cited here due to space restrictions.
Financial & competing interests disclosure
Work in the author’s laboratory is funded by the Canadian Institutes of Health Research and Heart & Stroke Foundation of Canada. The author has no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.