Impact of mTOR-I on fertility and pregnancy: state of the art and review of the literature

Marialuisa Framarino-dei-Malatesta Department of Gynecological-Obstetrical and Urological Sciences, University of Rome Sapienza, Italy; Department of Gynecological-Obstetrical and Urological Sciences, University of Rome Sapienza, Italy

Martina Derme Department of Gynecological-Obstetrical and Urological Sciences, University of Rome Sapienza, Italy; Department of Gynecological-Obstetrical and Urological Sciences, University of Rome Sapienza, Italy

Tommaso M Manzia General Surgery and Transplant Unit, University of Rome Tor Vergata, Italy. [email protected]; General Surgery and Transplant Unit, University of Rome Tor Vergata, Italy. [email protected]

Giuseppe Iaria General Surgery and Transplant Unit, University of Rome Tor Vergata, Italy; General Surgery and Transplant Unit, University of Rome Tor Vergata, Italy

Linda De Luca Renal Unit, University of L’Aquila, Italy; Renal Unit, University of L’Aquila, Italy

Laura Fazzolari Department of Clinical and Molecular Medicine, University of Rome Sapienza, Italy; Department of Clinical and Molecular Medicine, University of Rome Sapienza, Italy

Angela Napoli Department of Clinical and Molecular Medicine, University of Rome Sapienza, Italy; Department of Clinical and Molecular Medicine, University of Rome Sapienza, Italy

Pasquale Berloco Department of General Surgery and Transplant ‘Paride Stefanini’ University of Rome Sapienza, Italy; Department of General Surgery and Transplant ‘Paride Stefanini’ University of Rome Sapienza, Italy

Timil Patel Wake Forest School of Medicine, Winston Salem, NC, USA; Wake Forest School of Medicine, Winston Salem, NC, USA

Giuseppe Orlando Wake Forest School of Medicine, Winston Salem, NC, USA; Wake Forest School of Medicine, Winston Salem, NC, USA

Giuseppe Tisone General Surgery and Transplant Unit, University of Rome Tor Vergata, Italy; General Surgery and Transplant Unit, University of Rome Tor Vergata, Italy

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Abstract

Successful transplantation should lead to improvements in sexual function and sex hormone disturbances in both men and women, but immunosuppressive drugs may interfere with hormone metabolism. In this regard, several studies have showed a potential negative effect of mTOR inhibitors (mTORi) on male gonadal function, while their role in the female patients is not well documented in the literature. Successful pregnancy is possible after solid organ transplantation. The fetal effects of mTORi are still poorly defined but they seem not to represent an absolute contraindication for pregnancy. The aim of our study would be to review the impact of mTORi on fertility and pregnancy in order to have a clearer picture about their possible use after organ transplantation.

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Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

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Impact of mTOR-I on fertility and pregnancy: state of the art and review of the literature

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