Abstract
DNA microarrays are capable of following the level of expression of virtually all genes in a human tissue. This has been employed to determine aberrant gene-expression profiles in many skin diseases, including UV-light damage, inflammatory processes and cancers. Owing to its accessibility, skin served as one of the initial targets of basic research using DNA microarrays; both the epidermis and dermis have been extensively investigated. Development of bedside uses of DNA arrays, coupled with the concomitant price reduction of the materials and methods of microarray analyses, holds great promise for improved diagnosis, treatment and prevention of dermatologic disorders.
Financial & competing interests disclosure
The authors research is supported in part by a grant from National Institutes of Health, NR08029 and DebRA-UK Foundation with additional support from DebRA of America. We thank the NYU Genomics Facility for technical assistance with microarray analysis. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.