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Review

Thrombophilia and maternal mortality: risk factors and preventive approaches

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Pages 477-488 | Published online: 10 Jan 2014
 

Abstract

Pregnancy-associated venous thromboembolism continues to be a significant cause of maternal mortality and morbidity. Unfortunately, many of these deaths could be prevented by optimal prophylaxis and management. This review describes recent developments in the understanding of the pathophysiology of the disease processes and the contribution that thrombophilia makes. Potential strategies for identification of women at high risk and current and future therapeutic strategies for the prevention of venous thrombosis in pregnancy are also discussed.

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