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Genetic factors related to endometriosis: present and future

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Pages 791-801 | Published online: 10 Jan 2014
 

Abstract

Endometriosis is a multifactorial disease that affects 6–10% of women of reproductive age. Epidemiological studies indicate that it is a polygenic disorder, with recurrence risks in first-degree relatives of approximately 2–9%. Thus, the current task of different research groups is to identify genetic variations in an obvious candidate gene that could be associated with an increased susceptibility to endometriosis. The great advancement in molecular biology techniques certainly make this task possible, although particular attention needs to be paid to study design in order to achieve solid results. The data obtained by such studies will allow us to expand our knowledge of the pathogenesis of the disease and, more importantly, develop individualized therapies and prevention strategies to apply to high-risk populations.

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

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