Effect of sustained high altitude on asthma patients

Abstract

Due to factors such as allergen avoidance and the decrease of air pollution, sustained stays in a high-altitude climate have been recommended for asthma patients for a long time. There are also documented effects and favorable influence on the health of permanent residents at high altitude; for example, the frequency of allergic sensitization to house dust mite in asymptomatic subjects is much lower than at sea level. In the context of this article, ‘high altitude’ means 1500–2500 m above sea level. The aim of the review is to summarize the available data on the effects of a sustained stay of asthmatic patient data between 1500–1800 m above sea level in alpine altitudes (Europe). Climatic conditions in South America or in Africa are completely different from the altitudes discussed in this review. We conclude that the available evidence suggests a significant benefit of high altitude for asthmatic patients, particularly in steroid-dependent patients.

Keywords::

• airway hyper-responsiveness
• airway inflammation
• allergen avoidance
• high altitude
• immune modulation
• severe asthma

Financial & competing interests disclosure

The author has no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.