Abstract
Identification, prevention and reversal of age-related changes in the appearance and function of human skin remain goals of great interest to scientists, dermatologists and patients. In recent decades, the cellular and molecular changes that underlie cutaneous aging have been substantially elucidated. These data suggest that cutaneous aging, like aging in the body generally, results, in part, from a telomere-based genetic program, cumulative DNA damage and repair, oxidative damage, altered proteolysis and energy metabolism and changes in transcription factor-driven gene expression. In animal models, modulation of these events can delay or even reverse aging by many criteria. The resulting insights are likely to revolutionize the prevention and therapy of cutaneous aging.
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Financial & competing interests disclosure
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
No writing assistance was utilized in the production of this manuscript.