Abstract
Psoriasis is an inflammatory skin disease with characteristic changes in the epidermis that resembles unsuppressed wound healing due to excessive hyperproliferation of keratinocytes. The keratinocyte hyperproliferation is also accompanied by abnormal differentiation of cells. It is not clear how much keratinocytes contribute to disease pathology. In this article, the authors, however, attempt to summarize data that argue for the importance of abnormal keratinocyte behavior in the pathomechanism of psoriatic skin lesions.
Financial & competing interests disclosure
The authors were supported by the Hungarian Scientific Research Fund, OTKA K83277 and NK 77434 for their psoriasis-related research. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.