Role of TNF-α in human female reproduction

Abstract

TNF-α is a highly versatile cytokine, playing an important role in both apoptosis and inflammation, which is central to reproduction. It belongs to the Th1 type of cytokines. Thus, TNF-α is a proinflammatory cytokine and is involved during follicle development and ovulation, corpus luteum formation and regression and cyclic endometrium function. It has been postulated to be detrimental to the survival of the conceptus due to apoptosis of human primary villous trophoblast cells, leading to miscarriage. However, TNF-α may have a dual role in early pregnancy. Hormonally regulated uterine TNF-α in the mother is probably essential for trophoblast cell invasion, while increased production of TNF-α by maternal macrophages may facilitate labor. The current knowledge on the role of TNF-α and its receptors in the female reproduction is described in this review.

Keywords::

• cytokine
• female reproduction
• TNF-α
• TNF-α receptor
• tumor necrosis factor α

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.